Time to think

Time to think big in human biology?

Antiretroviral therapy: time to think strategically.

H active antiretroviral therapy (HAART), the use of combinations of antiretroviral drugs that can profoundly suppress HIV replication for prolonged periods, has substantially decreased AIDS-related morbidity and mortality in the United States and western Europe (1). However, the optimal use of antiretroviral drugs remains a rapidly evolving field and numerous obstacles need to be addressed. Man...

Parasite genomics—Time to think bigger

It has been more than 20 years since genomics approaches began to be applied to the problem of tropical neglected parasitic diseases in the form of pilot genome sequencing projects. The Plasmodium falciparum genome sequence was published in 2002 [1] as the result of an international collaborative effort, and the first reference genome sequences of Trypanosoma cruzi, Trypanosoma brucei and Leish...

Time to think outside the (genetic) box.

Many patients develop cancers that have clinical features of inherited syndromes (e.g., young age of onset and unique pathology) but lack mutations in the genes characteristic of the disease. In this issue of the journal, Wong et al. report that somatic epigenetic inactivation could explain some such cases in the setting of BRCA1-associated breast cancer. Here, we discuss the implications of th...

Teams Are Changing: Time to ‘‘Think Networks’’

Evolution is well underway in the area of teams. As Tannenbaum, Mathieu, Salas, and Cohen (2012) aptly convey, today’s teams are increasingly complex! Teams are no longer relatively straightforward extensions of individually-based jobs; rather, teams are increasingly capitalizing on technological advances joining together larger, more diverse, more highly specialized, and often distributed sets...